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Oct 21, 2011 · Superoxide dismutases are the major ROS detoxifying enzymes of the cell [69] and catalyze the dismutation of superoxide radicals to hydrogen ...
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Mar 20, 2001 · The 2.2 Å resolution X-ray structure of H30A-MnSOD shows that removing the Tyr174→His30 hydrogen bond from the acceptor side results in a ...
Dec 14, 2022 · Manganese superoxide dismutase (MnSOD) is a principal antioxidant enzyme that protects cells from oxidative damage by converting superoxide ...
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Apr 6, 2021 · Human manganese superoxide dismutase is a critical oxidoreductase found in the mitochondrial matrix. Concerted proton and electron transfers ...
Tumor utilizes increased levels of peroxide to signal the activation of transcription factors and upregulation of those proteins (such as HIF-1α, VEGF, NADPH ...
The crystal structures of the unfluorinated and fluorinated wild-type MnSOD are nearly superimposable with the root mean-square deviation for 198 α-carbon atoms ...
Mutation of Glu162 to alanine or aspartate in human MnSOD decreases enzymatic activity 5–25%, and increases product inhibition (discussed later) two-fold. While ...
Human Manganese Superoxide Dismutase (MnSOD) is a metalloprotein that prevents mitochondrial dysfunction by mitigating reactive oxygen species (ROS) in the ...
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Jan 3, 2024 · Functional characterization of a manganese superoxide dismutase from Avicennia marina: insights into its role in salt, hydrogen peroxide, and ...
The DNA repair enzyme endonuclease IV (endoIV), which is induced by superoxide, catalyzes the cleavage of DNA at apurinic/apyrimidinic (abasic or AP) sites ...